Call me crazy, but I've been using a Line 6 Flextone III 1x12 combo for years. I use three of the amp models. Most of the amp models somewhat approximate the intended amps, but only the Plexi 100, JCM Silver Jubilee and the Soldano mods do it for me. I've found the cabinet models are far more useful. You have to really fool with it though. I use a 1x12 open cabinet with the Soldano model and it just cooks. I'm fine with a hint of reverb, some modulation effects and echo, so the internal effects work fine. Really like the wah. The loop is switchable and programmable to the presets. Installed a gold leaf Marshall logo on the front. It looks like a Bluesbreaker. Fools everybody. Guitarists come up and tell me, "your Marshall sounds great". Serial can tell you. I've used a Duoverb when my amp was having power supply problems. Really dug it. I prefer a live mic, although the direct outs are really good.
Thinking about a Kemper profiling amp. I have so many friends with so many killer amps.