I’ve used them on Strats. After repeated attempts, they don’t stay installed for long.
Combined with a properly cut/lubricated nut, they can help a trem stay in tune. To my ear, they impart a bit of a, “sponginess”, to the tone that is not pleasing. If you have a particularly bright Strat you may like the effect. Don’t get me started on the TOM saddles, LOL.
Personally, for vintage Strat trems I prefer Highwood saddles. They’re designed with a small string channel and hex screws that don’t dig into the palm. Combined with Gotoh staggered, locking tuners my EJ Strat rarely loses tuning.
ETA: I see now that you have an American Std trem. Let us know how you like the stock saddles. IME they’ll be an improvement.